Major Depressive Disorder
At least 5 symptoms occur during the same 2-week period; depressed mood or loss of interest/pleasure must be among them.
Timing requirement
Duration
≥2 weeks
1 wk1 mo6 mo1 yr2 yr
Timing in context
Symptoms represent a change from prior functioning and cause clinically significant distress or impairment.
Sources and review
Last content review: August 21, 2026